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VEGF (vascular endothelial growth factor) induction was reported in certain models, without the transcriptional mechanism being fully dissected

Additionally, B12 increased the mRNA levels of HGF in the impaired group compared to the non-impaired group incubated with the excipient ( P = 0.0081)

J Pathol 234(4):538547

Thus, applying GHK-Cu may act as a repair signal that initiates skin recovery processes [13, 14]

These protocols help clinicians balance efficacy with safety, reducing the risk of severe complications while maintaining therapeutic intent

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