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Nevertheless, the Inverse Distance Weighting remains a valid technique for interpolating non-parametric, spatially heterogeneous data, serving as a visual aid if the results are interpreted conservatively

Therefore, if the pH of sachets is near pH 10, nicotine can be transformed into almost 99% freebase nicotine, which is more bioavailable and can cross the oral mucosa faster and more rapidly, increasing the amount of nicotine in the bloodstream [65]

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