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The job of SOD is evidently to catalyse the dissociation of the superoxide radical (O2.-) and, as a result, to eliminate this species from the system [reaction (I)] ( This species apparent cytotoxicity may be due to interactions with redox-active metal ions such as iron and copper, which promote the formation of a more reactive hydroxyl radical

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100 Nevertheless, these studies were performed using culture-based methods of bacterial detection and it may be necessary to re-assess the impact of cyclamate and acesulfame potassium on the gut microbial ecosystem using modern sequencing technologies