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A vial labeled "5 mg" from one compounder may differ meaningfully from another, raising the practical risk of accidental misdosing even when a patient follows a physician's written protocol

Your research protocol should pre-determine the doses you intend to study

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Osteonecrosis of the Jaw Osteonecrosis of the jaw has been reported with zoledronic acid [see Warnings and Precautions (5.4)]