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The binding of nicotine, as well as any other type of nAChR agonist, can alter the synaptic release of acetylcholine itself, as well as a wide range of other neurotransmitters such as dopamine, norepinephrine, serotonin, and glutamate

Between 1965 and 1990, the share of non-filtered cigarettes declined from 36% in 1965 to 5% in 1990 5

Blood concentration of nicotine rises quickly, and a high level of nicotine reaches the brain in 10 to 20 seconds

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