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Plasma treatment of serum-containing culture media results in significantly lower ROS levels than that those of the serum-free media, likely due to the components in FBS scavenging-specific ROS/RNS, thereby mitigating the influence of plasma treatment on tumor cells 33

These metabolic and transcriptional alterations were adaptive and allowed microglia to maintain their phagocytosis efficiency after LCI and in a model of irradiated glioblastoma

An example of combination therapy includes delta-tocotrienol with cisplatin where the combination resulted in downregulation of Notch-1 via inhibition of NFkB signaling pathways resulting in controlling non-small cell lung cancer, while reducing the effective dose of cisplatin [56] suggesting that effective treatment can be achieved with reduced side effects and toxicity of cisplatin

Lerner et al

SEI can improve the progression of AD through suppressing the NF-B activity, and thereby attenuating the production of inflammatory cytokines, oxidative stress, and apoptosis in endothelial cells (191)

Notably, the number of TUNEL-positive neurons, indicating DNA fragmentation and apoptosis, was also significantly decreased