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It was then accidently discovered, in a patient using cyclosporine, that psoriasis had a strong immunological component

APS is primarily absorbed through passive pathways in vivo , but its absorption efficiency is relatively low

To solve the paradox that pre-existing high concentrations of ROS in the TME can conversely inhibit immunity, the most advanced strategy is to develop multifunctional nanovaccines that first clear, then activate. Such vaccines can first use their material properties to scavenge the inhibitory ROS in the TME, creating a favorable environment for immune cells, and then strongly activate DCs by releasing immune agonists, ultimately triggering a systemic anti-tumor immunity [265]

Figure 6 5.2.1 Antioxidants Mitochondrial dysfunction is frequently associated with elevated oxidative stress levels, leading to cellular damage and exacerbating the inflammatory response (192)

Abcam, ab133524) to tissue microarrays (TMA, two cores per case) of formalin fixed and paraffin embedded (FFPE) NSCLC and SCLC specimens

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