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While the heartbeat of LMNA (WT) fish show slightly increased of heart rate compared to AB(WT) fish, we observed an elevated heartbeat in LMNA (E358K) and LMNA (A539V) fish, compared to LMNA (WT) fish (Fig

[Abstract]2024 Feb 29;38(4):e23491

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This evidence leads us to hypothesize that, in the cortical motor areas of SMA mice, dysregulations in PV + IN GABA synthesis trigger a disruption of inhibitory neurotransmission in the late disease stage, which occurs simultaneously and in response to late-stage impairment of Gln neuron-astrocyte transport and/or metabolism

That there pretty much everybodys going to have some benefit, but then theres a subset whos going to have a tremendous benefit, and we see the people who put their condition into remission where it was treatment-resistant otherwise