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Notably, this occurred in the absence of improved insulin sensitivity, neuroinflammation, brain mTORC1 signaling, or activation of brain autophagy all physiological and molecular changes that have been hypothesized to explain the ability of CR to slow the development or promote the clearance of A plaques

Front Neurol 15:1428036

389,390 Moreover, improvements in CRISPR-Cas9 technology present opportunities for accurate genetic and epigenetic alterations to rectify inherited genetic variants and epigenetic markers associated with DPN

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6.1 Mechanism of action of food bioactives on gut microbiota and inflammation Food bioactives such as polyphenols, flavonoids, and other bioactives demonstrate potential in ameliorating metabolic syndrome through multifaceted mechanisms (Afolabi et al., 2022

doi: 10.1038/s41586-020-2634-9 228 BuscarinuMCCerasoliBAnnibaliVPolicanoCLionettoLCapiMet al