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[Abstract] Life Metab

In Using Mathematics to Understand Biological Complexity , 135178 (Springer, 2020)

As a redox-active cofactor, BH4 directly scavenges PL-OOHs and indirectly promotes CoQ10 biosynthesis, thus conferring resistance to ferroptosis (Wang et al., 2024)

This concept, widely known as the oxidative burst, was foundationally established in seminal studies demonstrating that post-ischemic tissue injury is driven by oxygen-derived free radicals generated upon reoxygenation (Granger et al., 1981

Doing a liver detox might be en vogue these days, but properly supporting our detoxification pathways goes far beyond a few days of juicing

However, in Gclc- deficient FoB no GSH was detectable and these cells accumulated ROS (Fig