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LITERATURE REVIEW 1) Cigarette smoking effects on the respiratory epithelium The epithelium coating the upper respiratory tract acts as a first line of defense against invasive agents (pollutants, allergens, microorganisms), and it can cause upper airway symptoms and diseases when in contact with these agents.5 Inhaled cigarette smoke, both passively as well as actively, has been associated with chronic irritation and discomfort on the eyes, nose and oropharynx.6 Since 1964, when a report was published about smoking by the U.S

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Mammals devote a third of their genetic code to odor receptors found in the nose, and have more than 1,000 different kinds that allow us to smell an estimated trillion different odors

Over 11 percent of 6.4 million deaths worldwide were caused by smoking in 2015 and 52.2 percent of them took place in China, India, Russia, and the US, the report said