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Genome biology

However, results are dose-dependent and more effective when combined with a calorie-controlled diet or exercise program Could Help Prevent Fat Storage (Reduced Lipogenesis) Some animal studies suggest AOD9604 may limit the formation of new fat cells, known as lipogenesis (preclinical evidence)

Consistent with our earlier results, mitochondrial mass was not significantly changed in either control or IGF-1R cKO Th17 cells treated with IGF-1 (Fig

In diet-induced obese (DIO) mouse models, NNMT inhibition with 5-Amino-1MQ was associated with reduced white adipose tissue mass without affecting food intake, suggesting changes in energy expenditure rather than appetite suppression

Foundational mechanism paper

Its mechanism is purely metabolic: it directly targets lipid metabolism via inhibition of NNMT and restoration of cellular NAD+