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Subsequent studies revealed that co-infusion of GLP-1 with GCG can mitigate the GCG-induced hyperglycaemia [34], while preserving GCGs metabolic benefits, providing a strong rationale for the development of GLP1/GCG co-agonists as obesity treatments (Fig

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These regulatory effects may underlie observed improvements in sleep-wake patterns and neuroendocrine homeostasis in aged subjects [3]