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Antibiotic resistance : Overuse of antibiotics can cause bacteria to change in a way that makes it harder for the medication to work effectively in the future

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Whereas carbon monoxide may have a similar anti-inflammatory profile to exercise 123 and nicotine induces inhibition of microglia and reduces TNF- activation through the activation of the 7 nicotinic acetylcholine receptor (nAChR) 22,124,125,126,127,128 , tobacco exposure exerts acute pro-inflammatory effects by inducing the production of IL-1 and TNF- 129,130

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They may indicate early metabolic changes, but they may also reflect reverse causation, residual confounding, or behavioural differences between groups

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