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This reaction is catalyzed by the maintenance DNA methyltransferase (DNMT1) and de novo DNA methyltransferase enzymes (DNMT3A and DNMT3B), with S -adenosylmethionine (SAM) as the methyl donor [220, 222, 226, 229]

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[25 Odd Facts About Marijuana] The findings suggest that the reasons why people combine smoking cigarettes with drinking alcohol are different from the reasons they combine smoking cigarettes with smoking marijuana, said study co-author Johannes Thrul, a postdoctoral scholar at the University of California, San Francisco Center for Tobacco Control Research and Education