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Abstract Bioorthogonal reactions have revolutionized molecular biology through the conjugation of molecules within cellular environments

During viral load reduction experiments, honokiol was shown to reduce both viral RNA copy numbers and viral infectious progeny titres

doi: 10.1016/j.redox.2021.102058 140 ZhangY.ChenF.TaiG.WangJ.ShangJ.ZhangB.et al

Upon binding to TGF- type I and II receptors (TGFRI/II), TGF-1 activates the Smad2/3 signaling cascade

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A lower binding energy indicates a more stable interaction between the protein and the metabolite