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Diagnosis starts with ruling out other causes of chronic gastrointestinal issues, like infections or parasites

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There is supporting evidence reporting adverse effects from long-term rhIGF-1 treatment including neoplastic formation, cataract and renal hypertrophy, all of which seem to be the most severe effects observed and are usually rare [123, 282284]

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Fluid intake also often occurs without thirst sensation and without increased plasma osmolality ( McKiernan et al