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GPX4 plays a crucial role in regulating ferroptosis through its unique ability to reduce complex hydroperoxides, including phospholipid hydroperoxides and cholesterol hydroperoxides, effectively disrupting the lipid peroxidation chain reaction [58, 59]

Methylation connection: Impaired methylation or low cysteine reduces GSH synthesis, further limiting GSTP1 function

The efficacy of CsA-loaded PBA-modified NP formulations was compared to Restasis in induced mouse and rabbit dry eye experiments

By incorporating specific metabolic regulators or therapeutic molecules into the cargo of EVs, the versatility of EVs as drug delivery vehicles can be maximized, offering targeted interventions in various diseases

Inhibiting interactions of lysine demethylase LSD1 with Snail/Slug blocks cancer cell invasion

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