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Its extremely vulnerable to diseases and pests, which is why it evolutionary developed nicotine as a natural pesticide

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The second source notes: Nicotine is a natural product of tobacco, occurring in the leaves in a range of 0.5 to 7.5% depending on variety.[84] Nicotine also naturally occurs in smaller amounts in plants from the family Solanaceae (such as potatoes, tomatoes, and eggplant).[85] Reference 85 points back to the first link, which shows this table

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