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[DOI] [PMC free article] [PubMed] [Google Scholar] 130.Montuschi P., Collins J.V., Ciabattoni G., Lazzeri N., Corradi M., Kharitonov S.A., Barnes P.J

Since its early description as an endothelial-derived relaxing factor, NO has emerged as a fundamental signaling device regulating virtually every critical cellular function, as well as a potent mediator of cellular damage in a wide range of conditions

nevertheless, the pronounced heterogeneity observed in random-effects modelingpotentially attributable to geographic and diagnostic disparitiescalls for supplementary sensitivity analyses to sharpen interpretive precision [16]