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La prsence de formaldhydes (class cancrogne par le CIRC), de constituants potentiellement mutagnes (humectant et aromatisants) et cytotoxiques, pourrait influer sur le risque de cancer, notamment en cas dutilisation prolonge des vapoteuses

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Boxed Warnings and Precautions Initial labeling for Xarelto, as a part of its FDA approval in 2011, included two black box warnings. Black box warnings indicate that the drug could cause particularly dangerous side effects