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Oridonin induces hepatic CYP450 enzymes (e.g., CYP3A4, CYP2C9) in HepaRG cells and PXR-humanized mice, suggesting potential drug-drug interactions (Yi-Wen et al., 2018

Gyurszov M, Gureck R, Bbkov J, Tthov

However, their application is severely constrained by high catalyst costs and limited availability of raw materials (Li et al

Constantinescu, C

doi: 10.1136/bmj.b566

This effect was associated with increased expression of IGF-1 and VEGF in the primary ossification zone.103 Altogether, the bone anabolic actions of the GH can be, at least in part, mediated by paracrine IGF-1 signaling, which enhances osteoblast activity.104 In fact, the only administration of recombinant IGF-1 to healthy participants results in an increase in circulating levels of bone remodeling markers