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10.1074/jbc.M109.083121 32 ChauguleV

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2 Yinghua East Street, Chaoyang District, Beijing, 100029, Peoples Republic of China, Email [email protected] Abstract: Chronic obstructive pulmonary disease (COPD) is a complex and heterogeneous respiratory disorder that arises from interactions between genetic susceptibility and environmental exposures, with cigarette smoking being the primary modifiable risk factor

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It came to prominence in the 2010s, with reports in July 2014 showing its use had increased by 36% in the previous six months compared to the same period of 2013.[24] But just a few years later the sale of snuff fell from 46 tons in 2019 to 12.6 tons in 2022,[25] with the increasing popularity of nicotine pouches thought to be the main cause of this decline

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