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A pathologic increase in goblet cell density and increased staining of intracellular mucin in the ET are associated with actual goblet cell proliferation as well as mucin synthesis, storage, and exocytosis 18

therefore the consequences of smoking cannot be attributed only to nicotine [68]

In this regard, it is noteworthy that the mode of nicotine administration has to be carefully considered as the pharmacokinetic and pharmacodynamic of different nicotinic preparation can be significantly different [79]

In the last several decades, smoking has been banned in public places because of the risks of second-hand smoke

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