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There can be a bump in visitor traffic around school holidays, especially Thanksgiving and Christmas vacations

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A 2020 review of case reports found that self-administered coffee enemas caused adverse effects such as: abdominal pain bloody stool rectal pain or burning proctocolitis, or inflammation of the rectal lining colitis, or inflammation of the colon The review also noted three deaths following coffee enema

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For chronic wounds (diabetic ulcers, venous ulcers), GHK-Cu has been used in some specialty wound care programs

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