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Enhanced glutaminolysis in cancer cells ensures a stable supply of glutamate and -KG via sequential deamination processes inside mitochondria

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This transporter can also mediate uptake of oxidized VitC (dehydroascorbic acid, DHA) which is reduced back after uptake by the cell, resulting in depletion of intracellular antioxidants such as glutathione (GSH), nicotinamide adenine dinucleotide phosphate (NAPDH) and SOD enzymes, thereby further increasing reactive oxygen species (ROS) levels in cancer cells [32]

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Additionally, simvastatin is also highly lipophilic and can cross the bloodbrain barrier

Kim TW, Guan S, Sun Y, Deng Z, Tang W, Shang JX, Sun Y, Burlingame AL, Wang ZY (2009) Brassinosteroid signal transduction from cell-surface receptor kinases to nuclear transcription factors