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Cigarette smoke treatment of RPE cells recapitulated the chromatin accessibility changes seen in AMD, providing a potential epigenetic link of a known AMD risk factor with AMD pathology

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Ligand binding to subsite C influences specificity of NE uptake inhibition The structures of SNRIs duloxetine, milnacipran, and tramadol in complex with the dDAT show a progressively smaller aromatic moiety that interacts with the subsite B and C in the primary binding pocket of dDAT

Sousa, L., Oliveira, M

The development of a clinician-administered PTSD scale

Arousal and Subjective Response Studies An early proof-of-concept study in 18 premenopausal women with sexual arousal disorder evaluated intranasal PT-141 (20 mg) effects on physiological and subjective sexual response