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Histamine H Receptor Antagonist (H 2 RA)/Proton Pump Inhibitor (PPI) Induced Vitamin B 12 Depletion Literature suggests that drugs which suppress stomach acid production such as PPIs 159163 and HRAs 164167 interfere with vitamin B 12 absorption, by reducing dietary B12 release from food proteins

Albright SD, Kupfer HG, Kinne DR (1959) A study of coagulation factors in blood and spinal fluid in multiple sclerosis

This pattern supports both immediate replenishment and a foundation for ongoing B12 status

A deeper understanding and further studies of the correlation between p53 and metabolic diseases are needed to elucidate the underlying mechanisms for the development of potential clinical strategies