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HNE can react directly with the A peptide

504,505,506 GLP-1 enhances the insulin signaling pathway in the liver by activating the GLP-1R, especially through the phosphorylation of insulin receptor substrates and the activation of the PI3K/Akt signaling pathway, thereby increasing hepatic insulin sensitivity, facilitating glucose uptake and utilization, and reducing hepatic gluconeogenesis

Astrocytes converts these FAs into KBs, which are then transported to neurons to serve as metabolism of energy (Panov et al

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