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Cigarette smoking is the leading cause of preventable disease and death in the United States and is responsible for more than 480,000 deaths per year (Ref

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Furthermore, an estimated 8 million people are killed by tobacco particles annually, 7 million of whom die through direct tobacco use and 1 million of whom are non-smokers

Dysbiosis of Intestinal Microbiota and Systemic Disorders Intestinal microbiota exerts the key roles in the physiology of human being, and chronic cigarette smoking as an environmental factor induces dysbiosis of intestinal microbiota (Lee et al., 2018)

In 2026, 68% of them correctly thought that vapes are less harmful than smoking and 16% said that vapes are more or equally harmful (5% in 2019) (Figures 24 and 25)