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The most robust clinical evidence to date concerns the improvement of muscular and metabolic parameters (strength, endurance, insulin sensitivity) and the modulation of chronic inflammation. A 2024 randomised trial comparing NAD IV with NR IV in healthy adults showed that both modalities increase the available NAD pool, with a favourable safety profile

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Katagiri C, Masuda K, Urano T, Yamashita K, Araki Y, Kikuchi K, et al

ChehoudCAlbenbergLJudgeCHoffmannCGrunbergSBittingerKet alFungal signature in the gut microbiota of pediatric patients with inflammatory Bowel disease

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