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p62 is a key regulator of nutrient sensing in the mTORC1 pathway

There is evidence of some points that would be interesting for the treatment of lipedema, such as (1) reduction in lipogenesis and increase in lipolysis [32], increase in adiponectin levels, and reduction in leptin and insulin resistance [36], promotion of improvement in beta-oxidation in skeletal muscle with reduction in intramuscular fat accumulation, aid in appetite control and subcutaneous adipose tissue deposition [37]