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This kind of interaction is responsible for the neuroprotective effect against -amyloid-induced neurotoxicity in SH-SY5Y cells through the nicotine-mediated up-regulation of anti-apoptotic proteins Bcl-2, Bcl-xL and Mcl-1 (Xue et al

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Exposure to nicotine and the extent of its effects can also be influenced by individual differences in smoking behavior, metabolism, body mass index, and genetics