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Nature Medicine asks leading researchers to name their top clinical trial for 2025, from genetherapies for prion disease and sickle-cell disease to digital tools for cancer and mental health

A7r5 cells were cultured in the calcifying medium for 10 days and then washed three times with PBS after which calcium deposition was visualized and quantified by Alizarin Red (Solarbio, China) staining as recommended by the manufacturer

If your purifications are yielding close to 8 mg of GST-fusion protein per mL of glutathione resin, you are good to go

After 68 weeks at the 2.4 mg maintenance dose, participants achieved a mean body-weight reduction of 14.9% versus 2.4% for placebo

13 : R15

Consequently, the mechanism of GLS1 action is more clearly defined, and the targeted inhibition of GLS1 has potential for use in cancer therapy