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doi:10.1016/j.procbio.2006.06.030 Wieser H (2007) Chemistry of gluten proteins

Conjugation of TLR2 Pep to Maleimide Doped Oridonin-Liposome A cysteine (Cys) residue was synthetically appended to the C-terminal of the TLR2 targeting peptide, resulting in an amino acid sequence represented as His-Leu-Tyr-Val-Ser-Pro-Trp-Cys

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Failure to eliminate dysfunctional mitochondria leads to the accumulation of mitochondrial ROS and the release of immunogenic mtDNA, both of which act as DAMPs that activate innate immune pathways, including the NLRP3 inflammasome and type I interferon (IFN-I) signaling

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Moreover, elastin abnormalities may be caused by a deficiency in the Cu-dependent enzyme LOX ( 2+ and that NADPH causes DNA oxidation (Kankanamage et al., 2020)