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Neutrophils and macrophages infiltrating the inflamed gut release excessive ROS and cytokines such as TNF- and IL-1, exacerbating oxidative stress and amplifying ferroptosis-induced tissue injury (171)

Moreover, increased Bacteroides fragilis may account for the upregulation of IL-18, IL-1, and caspase-1, promoting an inflammatory response (Kiseleva et al., 2011)