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Consequently, innate immunity promotes the development of beneficial components of the microbiome and is involved in the maintenance of microbial ecological balance

Data Availability Statement Data for this review were identified by searches of MEDLINE, PubMed, and references from relevant articles using the search terms ketone bodies, -hydroxbutyric acid, ketogenic diet, SGLT2 inhibitors, and mitochondrial function and hormesis. In order to limit the number of references, more recently published papers referring to several previously published articles were cited, if possible

The mechanisms by which TMAO raises CV risk and accelerates atherosclerosis are not well understood, but studies have shown that TMAO arising from both choline and L-carnitine supplementation in mice may inhibit reverse cholesterol transport 35 and enhance foam cell formation in both arterial and peritoneal cavity 47

[DOI] [PubMed] [Google Scholar] 30.Lucafo M, Stankovic B, Kotur N, et al

J Mol Liq 212:331339