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Circulation 137 , 11431157 (2018)

Studies show that PD risk genes such as GBA, LRRK2, and PARK2 are also linked to lipid metabolism [82]

For this reason, smaller organoid systems may be preferred at the expense of low cellular diversity, loss of long-range connectivity, and electrophysiological properties that do not fully recapitulate disease states [225, 226]

It is worth noting that even among those men with levels between 40-50 U/I, a level considered to be in the normal range, a nearly 20-fold increase in risk was found

Although current evidence strongly supports its dynamic involvement in disease development, it remains uncertain whether OS acts primarily as an initiating factor, an amplifying mechanism, or a downstream consequence of placental dysfunction 27

Modulation of the gene expression of annulus fibrosus-derived stem cells using poly(ether carbonate urethane)urea scaffolds of tunable elasticity