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For instance, studies in germ-free or antibiotic-treated mouse and rhesus monkey models have demonstrated reduced levels of BBB tight junction proteins (e.g., claudin-5, occludin) and increased BBB permeability

Further investigations are needed to clarify the roles of CO and biliverdin in MERCs and the relationships with the MITOLHMOX2 pathway

*Correspondence: Xiaoyuan Zheng, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

PI3Ks are involved in a wide range of intracellular regulatory mechanisms, and their functional deregulation has been associated with a variety of human diseases (230)

Today's food preservation techniques include a range of physical methods, including freezing, refrigeration, thermal processing, and air-drying, as well as chemical techniques that employ nitrates, benzoates, and BHT, along with other chemical agents, organic acids and salts (Mafe et al., 2024)