acetaminophen napqi glutathione metabolism. NAPQI, N-acetyl-p-benzoquinone imine; CYP450, Acetaminophen toxicity - EMCrit Project
Acetaminophen toxicity EMCrit Project 3 Glutathione Rescue Normally, glutathione binds NAPQI and converts it into non toxic byproducts (cysteine + mercapturic acid) that are excreted. Example: Glutathione is your liver's safety net against toxins. Acetaminophen Pathway (toxic doses), Pharmacokinetics Pharm D Paracetamol is safe when used correctlybut overdose can be life threatening. Excess paracetamol leads to the accumulation of NAPQI, a Instagram Trapping of NAPQI, the intermediate toxic paracetamol metabolite, by aqueous sulfide (S2) and analysis by GCMS MS ScienceDirect NAPQI Wikipedia
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