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Through the maintenance and regulation of intracellular copper homeostasis, it partakes in modulating cellular physiological functions

ACE2 Angiotensin converting enzyme 2 ERK Extracellular signal-regulated kinase GAE Gallic Acid Equivalent HO-1 Heme oxygenase 1 HOMA-IR Homeostatic Model Assessment of Insulin Resistance iNOS Inducible nitric oxide synthase ICAM-1 Intercellular adhesion molecule-1 VCAM-1 Vascular cell adhesion molecule-1 IL Interleukin LPS Lipopolysaccharide MAPK Mitogen-activated protein kinase NSAIDs Nonsteroidal anti-inflammatory drugs Nrf1 Nuclear factor erythroid 2-related factor 1 Nrf2 Nuclear factor erythroid 2-related factor 2 NF-B Nuclear factor kappa B PPAR- Peroxisome proliferator activated receptor gamma PGI2 Prostacyclin PGE2 Prostaglandin E2 Akt Protein kinase B SF-36 Short Form-36 TXA2 Thromboxane A2 TMPRSS2 Transmembrane protease serine 2 TNF- Tumor necrosis factor-alpha WOMAC Western Ontario and McMaster Universities Osteoarthritis Index Glossary References 1

Zhou Q, Wang Y, Cheng Y, Zhou J, Liu W, Ma X, et al

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