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Remarkably, this simultaneous activation of ISR and OSRpreviously observed only in cancer cellswas shown to occur in normal tissues in mice in the cysteine-restriction group, with the two stress responses reinforcing each other

Cytochrome P450-derived versus mitochondrial oxidant stress in acetaminophen hepatotoxicity

Regulatory note: PE-22-28 is not FDA- or EMA-approved for human use

A mechanism for glutamate toxicity in the C6 glioma cells involving inhibition of cysteine uptake leading to glutathione depletion

doi: 10.1016/j.freeradbiomed.2018.01.010 157 ChigbrowMNelsonM

On the day of infection, THP-1 cells were washed and infected with mycobacteria at an MOI of five, then washed thrice after 4 hours to remove excess bacteria and resuspended in fresh antibiotic-free medium