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The fact that TRPM7 directly senses mechanical stimulation was, in fact, confirmed in human bone marrow mesenchymal stem cells by measuring suction-induced and hydrostatic pressure-induced membrane currents (Xiao et al., 2015) and in HEK293 cells transfected with mTRPM7 by observing pressure-induced cytosolic Ca 2+ increases (R

This typically resolves and is replaced by increased energy

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