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Ochratoxicosis in poultry: occurrence, environmental factors, pathological alterations and amelioration strategies

BPC (1,000 mcg) exerts its regenerative activity through VEGF-mediated angiogenesis supporting new capillary formation in healing tissue, growth hormone receptor upregulation amplifying fibroblast collagen synthesis and connective tissue repair, direct stabilization and restoration of intestinal epithelial tight junction proteins protecting and repairing the gut barrier from inflammatory and chemical damage, nitric oxide pathway activation supporting vascular and tissue perfusion, and antioxidant and inflammatory-modulating activity across multiple tissue compartments

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Necroptosis plays a dual role in tumour immune regulation, as it can activate antigen-specific immune responses by releasing damage-associated molecular patterns, while RIPK3/MLKL-mediated IL-1 release can suppress T-cell function and promote tumour immune escape [59]

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