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Long-term hypertension, diastolic dysfunction, increased cardiac after-load, myocardial fibrosis, alterations in coronary flow reserve, and ultimately left ventricular hypertrophy can result from endothelial failure besides vasoconstrictors up-regulation passageways (183)

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Other possible long-term effects of smoking Adderall are: Depression Severe insomnia Heart damage Anorexia Psychosis Paranoia Seizures Respiratory damage Lung cancer Additionally, long-term use of Adderall can lead to changes in the brains structure and function