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Chondroitin sulfate proteoglycan 4 functions as the cellular receptor for Clostridium difficile toxin B

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Large-scale chromatin reorganization reactivates placenta-specific genes that drive cellular aging

After activation, CD4 T cells proliferate and produces cytokines that orchestrate the immune response by promoting the activation, differentiation and functional modulation of other immune cell populations, as well as precisely regulating inflammatory processes

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Collectively, these findings underscore the important role of HIF-1 in mediating bone destruction in FLS of RA patients