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Our findings suggest that the altered EZH2/ H3K27me3/DAB2IP expression observed in COPD patients could be cause of an irregular proliferation in epithelial cells, present in the area of the metaplasia, known to be a pre-neoplastic change in response to toxic injury induced by cigarette smoke 5

Only two studies (5%) were longitudinal observational studies 17,20 , while 9 (23%) were cross-sectional studies 14,16,19,21,23,24,30,32,38 , 1 (3%) was a case report 15 , and 27 (69%) were cell/ in vitro or animal studies 18,22,25-29,31,33-37,39-52

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The study also found that no history of smoking was associated with a decreased risk of testing positive among patients with congestive heart failure (CHF), chronic obstructive pulmonary disease (COPD), and Parkinsons disease

Taxis and lorry cabs are considered workplaces, and so neither drivers nor passengers are allowed to smoke in those either

Between 2011 and 2012, the CDC reported that 36.8% of nonsmokers who lived in rental housing were exposed to secondhand smoke