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HIF1 also mediates glycolytic metabolism in murine neutrophils as conditional knockout of HIF1 drastically reduced ATP levels resulting in impaired bacterial killing (57)

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ADE caused by enhanced viral replication has been observed for other viruses that infect macrophages, including dengue virus 13,14 and feline infectious peritonitis virus (FIPV) 15

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The resulting pressure differential pulls contaminants back through the needle on every subsequent draw, degrading the peptide and increasing infection risk