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The table below compares the two approaches at a glance

Schumer, M

This includes a history of inadequate response to several different classes of anti-depressant medications with a trial of a minimum of 8 - 12 weeks each, along with augmentation strategies

Similarly, to enhance the efficacy of chain-breaking antioxidants, new derivatives with reduced toxicity and improved effectiveness, such as novel synthetic variants, various conjugates, or nanoformulations, specifically targeted to active sites of oxidative stress and particular ROS need to be developed

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Furthermore, the tonicity and viscosity of the formulation are critical factors that affect drug absorption and patient comfort (Dhuria et al., 2010)