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Human papillomavirus (HPV) may also play a role

As a result, the smoking epidemic is met mainly with inaction, even though smokers in the region typically consume up to 500 more cigarettes than smokers outside the area

245,246 In a randomized controlled trial involving patients with essential hypertension, specific SLC22A12 single nucleotide polymorphisms (SNPs), such as rs11602903, were associated with higher body mass index (BMI), larger waist circumference, higher HDL cholesterol levels, and the presence of metabolic syndrome in individuals of European descent

Left ventricular dilatation and the risk of congestive heart failure in people without myocardial infarction

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